Research

Our lab uses computational modeling and wet-lab experimentation in a broad portfolio of research projects in applications of regenerative medicine, cancer biology, immunoengineering, cellular manufacturing and precision medicine. A common thread among our projects is the development of new computational approaches for studying collective behavior in multicellular systems and the role of metabolism in influencing cellular  fate decisions in response to external cues. Please read more about our various projects below.

9/21/17

Our collaborative project with co-PIs Cristina Furdui (Wake-Forest) and Dave Boothman (UTSW) has been awarded a 5 year U01 from NCI to develop predictive models of chemotherapeutic responses in head and neck cancer.

9/14/17

Match day! Andre Norfleet and Andy Raddatz are joining the lab as 1st year BioE and BME PhD students.

9/12/17

The Kemp lab is thrilled to be participating in the new NSF-sponsored Engineering Research Center on Cellular Manufacturing and Technologies (CMaT)! This $20 million award brings together researchers to solve challenges in characterizing, modeling, monitoring, and distriubting materials needed to expand cell-based therapies.

Lewis J.E., Costantini F., Mims J., Chen X., Furdui C., Boothman D.A., Kemp M.L. “Genome-scale modeling of NADPH-driven β-lapachone sensitization in head and neck squamous cell carcinoma”. Antioxidant Redox Signaling. 2017 (in press).

Kniss-James, A.S., Rivet, C.A., Chingozha, L., Lu, H., Kemp, M.L. “Single-cell resolution of intracellular T cell Ca2+ dynamics in response to frequency-based stimulation”. Integrative Biology, DOI: 10.1039/C6IB00186F, 2017.

Prasanphanich, A.F., White, D.E., Gran, M.E., Kemp, M.L. “Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay”. PLoS Computational Biology, Nov 16;12(11):e1005188, 2016.