How intracellular and extracellular environments control the transmission of cellular information is important for our understanding of cellular function. Our lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. We rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation. 

We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.


Douglas White receives a prestigious graduate fellowship from the Atlanta ARCS chapter. Read more about his honor here


Adam Prasanphanich defends his doctoral dissertation "Dynamic Redox Signaling During TGF-Beta Induced Epithelial-Mesenchymal Transition" in partial fulfillment of the Emory Medical Scientist Training Program. Congratulations, Adam!


Ariel Kniss is awarded as one of 4 inaugural students selected for an NIH T32 competitive training grant in Computational Biosciences at Georgia Tech. She will join other graduate students across the Colleges of Science, Engineering, and Computing for this program.





Kippner, L.E., Kim, J., Gibson, G., Kemp, M.L. “Single Cell Transcriptional Analysis Reveals Novel Innate Immune Cell Types”. PeerJ 2:e452; DOI 10.7717/peerj.452, 2014.

Kniss, A., Lu, H., Jones, D.P., Kemp, M.L. “A microfluidic systems biology approach for live single-cell mitochondrial ROS imaging”. Methods in Enzymology, 526: 219-30, 2013.

White, D.E., Kinney, M.A., McDevitt, T.C., Kemp, M.L. "Spatial pattern dynamics of 3D stem cell differentiation via rules-based computational modeling. PLoS Computational Biology, 9(3):e1002952, 2013.

Sarkar, S., Payne, C.K., Kemp, M.L. "Conditioned media downregulates expression of Nrf2". Cellular Molecular Bioengineering, 6(2):130-137, 2013.