Aging, stem cell differentiation, cancer metastasis, and inflammation rely on progressive changes in metabolism. It is not fully clear how and why metabolic changes take place, but the consequence is an increase in the levels of reactive oxygen species. Collectively, the accumulation of these molecules is known as cellular oxidation, and pathological levels are referred to as oxidative stress. Our lab develops systems biology tools for analyzing how cellular oxidation influences cellular decisions. We are interested in the collective behavior that arises during stem cell differentiation, immune cell responses, or drug treatments from metabolic diversity in individual cells. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how protein networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput single cell techniques for the detection and quantification of intracellular oxidation.

We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Engineered Biosystems Building.


Our paper describing a microtubule-bound hydrogen peroxide sensor in collaboration with the Payne lab is accepted to Scientific Reports! Co-first author is undergraduate Tatiana Netterfeld, the first time an undergrad in the lab has headed a manuscript. Congratulations to Tatiana and Saheli Sarkar for this outstanding work!


October has been a big month for the lab. Two major NIH awards with Kemp lab participation are announced. A transformative R01 led by Tom Barker in pulmonary fibrosis (press release here) and the National Exposure Assessment Laboratory at Emory (NEALE), part of the new NIEHS Children's Health Exposure Analysis Resource (press release here). We are excited to be participants in the Director's Common Fund for High Risk High Reward research once more!


Gaurav Dwivedi's manuscript "Dynamic Redox Regulation of IL-4 Signaling" is accepted in PLoS Computational Biology. This marks the culmination of many years of Gaurav's Ph.D. Great job, Gaurav!

IBB issues a press release on our Integrative Biology paper. Read more about our pattern recognition platform here!

*Warren, E.A.K., *Netterfield, et al. “Spatially-resolved Intracellular Sensing of Hydrogen Peroxide in Living Cells”. Scientific Reports 2015 (accepted).

Dwivedi, G., et al. “Dynamic Redox Regulation of IL-4 Signaling”. PLoS Computational Biology (accepted)

White, D.E., et al. “Quantitative Multivariate Analysis of Dynamic Multicellular Morphogenic Trajectories”, Integrative Biology, DOI:10.1039/c5ib00072f, 2015.

*He L, *Kniss A, et al. "An automated platform enabling dynamic stimuli delivery and cellular response readout for high-throughput single-cell signaling studies". Lab on a Chip, 15(6):1497-507, 2015.