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How intracellular and extracellular environments control the transmission of cellular information is important for our understanding of cellular function. Our lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. We rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation. 

We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.

3/5/15

Douglas White defends his doctoral dissertation "Analyzing Multicellular Interactions: A Hybrid Computational and Biological Pattern Recognition Approach". Well done, Doug!

1/6/15

Douglas White receives a prestigious graduate fellowship from the Atlanta ARCS chapter. Read more about his honor here

12/16/14

Adam Prasanphanich defends his doctoral dissertation "Dynamic Redox Signaling During TGF-Beta Induced Epithelial-Mesenchymal Transition" in partial fulfillment of the Emory Medical Scientist Training Program. Congratulations, Adam!

8/4/14

Ariel Kniss is awarded as one of 4 inaugural students selected for an NIH T32 competitive training grant in Computational Biosciences at Georgia Tech. She will join other graduate students across the Colleges of Science, Engineering, and Computing for this program.

 

 

 

 

He L, Kniss A, San-Miguel A, Rouse T, Kemp ML, Lu H. An automated platform enabling dynamic stimuli delivery and cellular response readout for high-throughput single-cell signaling studies. Lab on a Chip, 15(6):1497-507, 2015.

Prasanphanich, A.F., Arencibia, C.A., Kemp, M.L. “Redox Processes Inform Multivariate Transdifferentiation Trajectories Associated with TGFβ-Induced Epithelial-Mesenchymal Transition”. Free Radical Biology & Medicine, 76:1-13, 2014.

Kippner, L.E., Kim, J., Gibson, G., Kemp, M.L. “Single Cell Transcriptional Analysis Reveals Novel Innate Immune Cell Types”. PeerJ 2:e452; DOI 10.7717/peerj.452, 2014.