How intracellular and extracellular environments control the transmission of cellular information is important for our understanding of cellular function. Our lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. We rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation. 

We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.

4/15/14 Ariel Kniss is awarded a $15K supplemental scholarship for her graduate studies through the Georgia P.E.O. chapter. Congratulations, Ariel!

3/6/14 Gaurav Dwivedi successfully defends his Bioinformatics Ph.D. "Computational modeling of the IL-4 pathway to understand principles of systemic redox regulation in cell signaling".

11/5/13 Douglas White receives a student travel award for his talk "Quantitatively Assessing Spatial Patterns of Differentiation in Aggregates of Mouse Embryonic Stem Cells" at TERMIS-AM!

10/29/13 Tatiana Netterfield is honored with a Presidential Undergraduate Research Award for the spring term!

7/30/13 Douglas White is selected for the Medtronic Excellence in Modeling award at the 2013 Annual BMES meeting with a $2500 cash prize!


Kippner, L.E., Kim, J., Gibson, G., Kemp, M.L. “Single Cell Transcriptional Analysis Reveals Novel Innate Immune Cell Types”. PeerJ 2:e452; DOI 10.7717/peerj.452, 2014.

Kniss, A., Lu, H., Jones, D.P., Kemp, M.L. “A microfluidic systems biology approach for live single-cell mitochondrial ROS imaging”. Methods in Enzymology, 526: 219-30, 2013.

White, D.E., Kinney, M.A., McDevitt, T.C., Kemp, M.L. "Spatial pattern dynamics of 3D stem cell differentiation via rules-based computational modeling. PLoS Computational Biology, 9(3):e1002952, 2013.

Sarkar, S., Payne, C.K., Kemp, M.L. "Conditioned media downregulates expression of Nrf2". Cellular Molecular Bioengineering, 6(2):130-137, 2013.