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How intracellular and extracellular environments control the transmission of cellular information is important for our understanding of cellular function. Our lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. We rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation. 

We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.

11/5/13 Douglas White receives a student travel award for his talk "Quantitatively Assessing Spatial Patterns of Differentiation in Aggregates of Mouse Embryonic Stem Cells" at TERMIS-AM!

10/29/13 Tatiana Netterfield is honored with a Presidential Undergraduate Research Award for the spring term!

7/30/13 Douglas White is selected for the Medtronic Excellence in Modeling award at the 2013 Annual BMES meeting with a $2500 cash prize!

 

White, D.E., Kinney, M.A., McDevitt, T.C., Kemp, M.L. "Spatial pattern dynamics of 3D stem cell differentiation via rules-based computational modeling. PLoS Computational Biology, 9(3):e1002952, 2013.

Sarkar, S., Payne, C.K., Kemp, M.L. "Conditioned media downregulates expression of Nrf2". Cellular Molecular Bioengineering, 6(2):130-137, 2013.

Li, Y., Dwivedi, G., Huang, W., Kemp, M.L., Yi, Y. "Quantification of degeneracy in biological systems for characterization of functional interactions between modules". Journal of Theoretical Biology, 302:29-38, 2012.

Dwivedi, G., Kemp, M.L. "Systemic redox regulation of cellular information processing". Antioxidants & Redox Signaling, 16(4):374, 2012.

Platt, M.O., Kemp, M.L. "T-cell phosphokinome as a fingerprint of graft versus leukemia". Frontiers in Bioscience, Jan 1(4):721 2012.