Publications

 

2016 -

 Lewis J.E., Costantini F., Mims J., Chen X., Furdui C., Boothman D.A., Kemp M.L. “Genome-scale modeling of NADPH-driven β-lapachone sensitization in head and neck squamous cell carcinoma”. Antioxidant Redox Signaling. doi:10.1089/ars.2017.7048, 2017.

Kniss-James, A.S., Rivet, C.A., Chingozha, L., Lu, H., Kemp, M.L. “Single-cell resolution of intracellular T cell Ca2+ dynamics in response to frequency-based stimulation”. Integrative Biology, DOI: 10.1039/C6IB00186F, 2017.

Prasanphanich, A.F., White, D.E., Gran, M.E., Kemp, M.L. “Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay”. PLoS Computational Biology, Nov 16;12(11):e1005188, 2016.

*Rivet, C.A., *Kniss, A., Gran, M.A., Potnis, A., Hill, A., Lu, H., Kemp, M.L. “Calcium dynamics of ex vivo long-term cultured CD8+ T cells are regulated by age related changes in redox metabolism”. PLoS One,11(8):e0159248, 2016.

Briers, D., Haghighi, I., White, D., Kemp, M.L. Belta, C. Pattern Synthesis in a 3D Agent-Based Model of Stem Cell Differentiation. 55th IEEE Conference on Decision and Control, 2016.

Runa, S., Khanal, D., Kemp, M., Payne, C. “TiO2 Nanoparticles Alter the Expression of Peroxiredoxin Anti-Oxidant Genes”. Journal of Physical Chemistry Part C, 120 (37), pp 20736–20742, 2016.

 

2011-2015

*Warren, E.A.K., *Netterfield, T.S., Sarkar, S., Kemp, ML, Payne, C.K.. “Spatially-resolved Intracellular Sensing of Hydrogen Peroxide in Living Cells”. Scientific Reports 5:16929, 2015.

Dwivedi, G., Gran, M.A., Bagchi, P., Kemp, M.L. “Dynamic Redox Regulation of IL-4 Signaling”. PLoS Computational Biology DOI:10.1371/journal.pcbi.1004582, 2015.

White, D.E., Sylvester J.B., Kinney M.A., Levario T.J., Lu, H., Streelman J.T., McDevitt, T.C., Kemp, M.L. “Quantitative Multivariate Analysis of Dynamic Multicellular Morphogenic Trajectories”, Integrative Biology, DOI:10.1039/c5ib00072f, 2015.

He L, Kniss A, San-Miguel A, Rouse T, Kemp ML, Lu H. "An automated platform enabling dynamic stimuli delivery and cellular response readout for high-throughput single-cell signaling studies". Lab on a Chip, 15(6):1497-507, 2015.

Prasanphanich, A.F., Arencibia, C.A., Kemp, M.L. “Redox Processes Inform Multivariate Transdifferentiation Trajectories Associated with TGFβ-Induced Epithelial-Mesenchymal Transition”. Free Radical Biology & Medicine, 76:1-13, 2014.

Kippner, L.E., Kim, J., Gibson, G., Kemp, M.L. “Single Cell Transcriptional Analysis Reveals Novel Innate Immune Cell Types”. PeerJ 2:e452; DOI 10.7717/peerj.452, 2014.

Kniss, A., Lu, H., Jones, D.P., Kemp, M.L. “A microfluidic systems biology approach for live single-cell mitochondrial ROS imaging”. Methods in Enzymology, 526: 219-30, 2013.

White, D.E., Kinney, M.A., McDevitt, T.C., Kemp, M.L. "Spatial pattern dynamics of 3D stem cell differentiation via rules-based computational modeling." PLoS Computational Biology, 9(3):e1002952, 2013.

Sarkar, S., Payne, C.K., Kemp, M.L. "Conditioned media downregulates expression of Nrf2". Cellular Molecular Bioengineering, 6(2):130-137, 2013.

Nair, R. Ngangan, A.V., Kemp, M.L., McDevitt, T.C. "Gene expression signatures of extracellular matrix and growth factors during embryonic stem cell differentiation. PLoS One, 7(10): e42580, 2012.

Li, Y., Dwivedi, G., Huang, W., Kemp, M.L., Yi, Y. "Quantification of degeneracy in biological systems for characterization of functional interactions between modules". Journal of Theoretical Biology, 302:29-38, 2012.

Dwivedi, G., Kemp, M.L. "Systemic redox regulation of cellular information processing". Antioxidants & Redox Signaling, 16(4):374, 2012.

Platt, M.O., Kemp, M.L. "T-cell phosphokinome as a fingerprint of graft versus leukemia". Frontiers in Bioscience, Jan 1(4):721, 2012.

Finn, N.A., Kemp, M.L. "Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kB activity in leukemic cells". Molecular Biosystems, 8(2):650, 2011.

Chung, K., Rivet, C.A., Kemp, M.L. Lu, H. "Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array". Analytical Chemistry, 83(18):7044-52, 2011.

Kippner, L.E., Finn, N.A., Shukla, S., Kemp, M.L. "Systemic remodeling of the redox regulatory network due to RNAi perturbations of glutaredoxin 1, thioredoxin 1, and glucose-6-phosphate dehydrogenase". BMC Systems Biology, 13(5): 164, 2011.

Finn, N.A., Findley, H.W.,  Kemp, M.L. “A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity”. PLoS Computational Biology, 7(9):e1002151, 2011.

Rivet, C.A., Hill, A.S., Lu, H., Kemp, M.L. "Predicting cytotoxic T cell age from multivariate analysis of static and dynamic biomarkers" Molecular and Cellular Proteomics, 10(3), 2011.
 

2002-2010

Adimora N.J., Jones, D.P., Kemp, M.L. "A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses". Antioxidants & Redox Signaling, 13(6):731-43, 2010.

Hirsch, A., Rivet, C., Zhang, B., Kemp, M.L., Lu, H. "Parallel multi-time point cell stimulation and lysis on-chip for studying early signaling events in T-cell activation", Lab on a Chip, 9:536-544, 2009.

Kemp, M., Go, Y.M., Jones, D.P. “Non-equilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology”. Free Radical Biology and Medicine, 44(6):921-37, 2008.

Wille, L., Kemp, M.L., Sandy, P., Lewis, C.L., Lauffenburger, D.A. “Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production”. Molecular Immunology, 44(12):3085-91, 2007.

Kemp, M.L., Wille, L., Lewis, C.L., Nicholson, L., Lauffenburger, D.A. “Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response”. Journal of Immunology, 178(8):4984-92, 2007.

Vinnakota, K., Kemp, M.L., Kushmerick, M.J. “Dynamics of Muscle Glycogenolysis Modeled with pH Time-Course Computation and pH Dependent Reaction Equilibria and Enzyme Kinetics”. Biophysical Journal, 91(4):1264-87, 2006.

Lambeth, M.J., Kushmerick, M.J., Marcinek, D.J., Conley, K.E. “Basal glycogenolysis in mouse skeletal muscle: in vitro model predicts in vivo fluxes”. Molecular Biology Reports, 29 (1-2):135-139, 2002.

Lambeth, M.J., Kushmerick, M.J. “A computational model for glycogenolysis in skeletal muscle”. Annals of Biomedical Engineering, 30 (6):808-827, 2002

Link to PubMed Citations