It’s been a long time coming, but the 3rd edition of A First Course in Systems Biology is now in print! The book is available at discount from the publisher and also for purchase on Amazon. This edition has lots of great new material including an introduction to agent-based and multiscale modeling, a deeper account of biological design principles and the optimization of metabolic flux distributions. We also discuss current topics of synthetic biology, personalized medicine and virtual clinical trials. I’m excited to use this text in BMED 3520 next fall!