Andrew Jin, Saif Khan
Collaborators: Ron Weiss (MIT), Calin Belta (Boston U.)
Funding Sources: NIBIB R01EB030946
Related links: CMaT, MCELS@GT-Emory, SCMB
We are combining synthetic biology and advanced computational techniques to accelerate an ongoing revolution — the application of human induced pluripotent stem cells (hiPSCs) to regenerative and personalized medicine. We are integrating new genetic circuits into hiPSCs that sense changes in the environment and internal molecular levels and activate expression of other genes in order to redirect organoid differentiation to desired outcomes with specific 3D organization and arrangements of cell types and functions. Our design of sophisticated gene regulatory networks is based on advanced optimization techniques rooted in control theory and machine learning, enabling precise and predictable generation of desired 3D structures and organoid functions.
Related Publications
Wauford, N., Patel, A., Tordoff, J., Enghuus, C., Jin, A., Toppen, J., Kemp, M.L., Weiss, R. “Synthetic symmetry breaking and programmable multicellular structure formation”. Cell Systems, 2023, in press.
Kamm, R.D, Bashir, R., Arora, N., Dar, R.D., Gillette, M.U., Griffith, L.G., Kemp, M.L., Kinlaw, K., Levin, M., Martin, A.C., McDevitt, T.C., Nerem, R.M., Powers, M.J., Saif, T.A., Sharpe, J., Takayama, S., Takeuchi, S., Weiss, R., Ye, K., Yevick, H.G., Zaman, M.H. “Perspective: The promise of multi-cellular engineered living systems”. APL Bioengineering, 2(4): 040901. doi: 10.1063/1.5038337, 2018.
Mehdipour N., Briers D., Haghighi I., Glen C., Kemp M.L., Belta C. “Spatial-Temporal Pattern Synthesis in a Network of Locally Interacting Cells”. 57th IEEE Conference on Decision and Control, 2018.
Briers D., Haghighi, I., White, D., Kemp, M. Belta, C. “Pattern Synthesis in a 3D Agent-Based Model of Stem Cell Differentiation”. 55th IEEE Conference on Decision and Control, 2016.